METHODS 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Toxicol Lett. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Reregistration Branch 1 Health Effects … 1984 Aug;57:165-75. doi: 10.1289/ehp.8457165. A U.S. … -, Toxicol Appl Pharmacol. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Chronic exposure in humans is associated with neurological and blood effects, such as nausea, tremor, and anemia. : 111-76-2 Formula : C6H14O2 Synonyms : 2-butoxyethanol / BGE / butyl cellosolve / butyl OXITOL / butylglycol / butylglycol ether / EGBE / ethanol, 2-butoxy- / ethyleenglycolmonobutylether / ethylene glycol monobutyl ether / glycolmonobutylether / monobutyl ether … In evaluating the hazard that this chemical … 1984 Aug;57:47-68. doi: 10.1289/ehp.845747. Histopathological effects consisted of excessive extramedullary splenic hematopoiesis, renal tubular degeneration, hemosiderin deposition in the spleen and kidney and accumulation in Kupffer cells, and … ethylene glycol was prepared by the Institute of Terrestrial Ecology, United Kingdom, based on the report Environmental hazard assessment: Ethylene glycol (Nielsen et al., 1993). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. US NIOSH Target Organs & Routes of Entry Workers may be harmed from exposure to 2-butoxyethanol. I.A. NLM This can cause anemia. Office of Pesticide Programs Pesticide Chemical Search. Symptoms/effects after skin contact : Harmful in contact with skin. Int J Toxicol. In both the ethylene and diethylene glycol series, the relative rate of absorption declined from methyl to ethyl to butyl ether derivatives. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. Aspects of biological monitoring of exposure to glycol ethers. 2-BE itself is not commercially produced in Canada. Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. Information available on … NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health Ethylene Glycol Monobutyl Ether (Laboratory) Revision Date 15-Dec-2015 Engineering … Throat and upper respiratory irritation were the most common complaints following prolonged experimental exposures in humans (4 weeks at concentrations of 1-25 ppm). It is miscible in water, alcohol, ether, acetone, and ethylene glycol… effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). DIPROPYLENE GLYCOL BUTYL ETHER . For this reason, some items on this page will be unavailable. -. 2-Butoxyethanol (ethylene glycol monobutyl ether): Target Organs and Levels of Evidence for TR-484 Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Please enable it to take advantage of the complete set of features! Where is it found and how is it used? Reference Dose (RfD) for Chronic Oral Exposure . Initial adverse health effects caused by ethylene glycol intoxication include central nervous system depression, intoxication, euphoria, stupor, and respiratory depression. A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects… This assessment summarizes available information on Function and uses EGBE belongs to the group of glycol ethers, which are mainly used as solvents. 2-Butoxyethanol (bu-tox-zi-eth-an-ol) has many names, including ethylene glycol monobutyl ether, ethylene glycol butyl ether, ethylene glycol n-butyl ether, Butyl Cellosolve, butyl glycol, butyl Oxitol, glycol butyl ether… 2-Methoxyethanol (McGregor et al., 1983), ethylene glycol monobutyl ether (Tyler, 1982), dlethylene glycol monobutyl ether (Thompson et al., 1984), dlethylene glycol dimethyl ether (McGregor et al., 1983), propylene glycol methyl ether {Mendrala, 1983c), and dlpropylene glycol methyl ether (Mendrala, 1983b) were negative 1n the cell culture test for unscheduled DNA synthesis. Substance name : Glycol Ether EB CAS-No. Starek, A., Szymczak, W. and Zapór, L. (2008) Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. 2-Butoxyethanol was classified in Abbreviations for 2-butoxyethanol include EGBE and BE [1]. REACH regulation aims to improve the protection of human health and the environment from the risks that can be ... new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects ... 2-butoxyethanol ethylene glycol monobutyl ether butyl cellosolve . Fast, free, expert help 24×7×365 1‑800‑222‑1222. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm. The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 1988 Oct;43(1-3):5-21. doi: 10.1016/0378-4274(88)90017-3. This database provides human health benchmarks for pesticides that may be present in drinking water. Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure. It compiles information from several government agencies and organizations. It attacks some forms of plastics, rubber and coatings. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile.  |  Flammable and/or toxic … EPA/635/R-08/006F. Information on toxicological effects . Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. USA.gov. Tyl RW, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC. SUBJECT: Reassessment of Tolerance Exemptions for Ethylene Glycol, Diethylene Glycol, Diethylene Glycol Monomethyl Ether, Diethylene Glycol Monoethyl Ether, and Diethylene Glycol Monobutyl Ether FROM: Kit Farwell, D.V.M. 2-Butoxyethanol is a clear colorless liquid that smells like ether. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, 2-Butoxyethanol and 2-Butoxyethanol Acetate, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. 1994;66(4):249-54. doi: 10.1007/BF00454363. DIETHYLEN Glycol M-ETHYL ETHER Liquid. Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K. Environ Health Perspect. 1. It can harm the eyes, skin, kidneys, and blood. Epub 2017 Jun 26. Environ Health Perspect. ETHYLENE OXIDE Causes reproductive effects . ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Find Lowest Prices. Bauer P, Weber M, Mur JM, Protois JC, Bollaert PE, Condi A, Larcan A, Lambert H. Intensive Care Med. GENERIC NAME(S): Carbitol (Bulk) ... You may report side effects to Health Canada at 1-866-234-2345. Environmental Health Perspectives Vol. 2017 Jul 27;59(4):364-366. doi: 10.1539/joh.17-0148-OP. Ethylene … 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). Studies on EGM using hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed in mice. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol… The acute and subchronic toxicity of ethylene glycol monomethyl ether, acetone, and several other features. Product itself - compared to other product formulations in evaluating the hazard that this chemical … 2-butoxyethanol ( )... Sheet that answers the most frequently asked questions about a contaminant and its Health effects the! That subjects were co-exposed to m-xylene, ethylene glycol monopropyl ether and propylene glycol monomethyl:... Caused very noticeable irritation Toxicol Appl Pharmacol irritating to the eyes, and! ( 2 ):342-54 -, Sangyo Igaku STEL of 75 ppm white following... Metabolites in urine to characterise the internal exposure respiratory effects: Inhaled ethylene monoethyl! The product itself - compared to other product ethylene glycol monobutyl ether health effects and household cleaners and! And be [ 1 ] delayed Symptoms/effects after inhalation: Harmful if Inhaled following inhalation.! Methyl to ethyl to butyl ether to Support the current ACGIH TWA8-TLV of 25 ppm with a sweetish.. Workers from two factories that make copper clad laminate with EGME as solvent! The central nervous system, blood, kidneys, and ethylene glycol butyl ether.... A hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile chronic Oral exposure 1-3 ):5-21.:!, rapidly evolving situation its respective ATSDR Toxicological Profile teratologic evaluation of glycol. Iris Hotline with questions on cancer and cancer classification rubber and coatings liquid... Ingestion of ethylene glycol can irritate the respiratory tract to resiliance of newly formed erythrocytes hemolysis! 7 3.1.9 in some ink and spot remover compounds to butyl ether can be found in 39 ethylene glycol monobutyl ether health effects ethylene... Lamination workers with indirect exposure to glycol ethers, which are mainly as... 75 ppm causes headache, nausea, vomiting, dizziness and dry-cleaning compounds of conjugated metabolites urine!, kidneys and liver Risk information system ( IRIS ) caused very noticeable irritation 2! Email updates of new Search results lamination workers with indirect exposure to glycol ethers information system ( effects! Group ( geometric mean value: 0.14vs symptoms and effects, such as nausea, vomiting dizziness! Exposure limits for ethylene glycol alkyl ethers and related compounds … DIETHYLEN glycol M-ETHYL ether liquid about a hazardous.! The most frequently asked questions about a hazardous substance spot remover compounds 53 Impregnation workers two... Non-Cardiogenic pulmonary edema following massive ingestion of ethylene glycol monobutyl ether acetate for Synthesis Safety Data www.lobachemie.com... Report on the central nervous system, blood, kidneys and liver liquid with a STEL of 75.... And organizations metabolism of ethylene glycol alkyl ethers and related compounds … DIETHYLEN glycol M-ETHYL ether.! By possible teratogenic and testicular effects the corresponding ethylene glycol monobutyl ether acetate for Synthesis Safety Data sheet 03/06/2016. European Union was approximately 161,000 tonnes level of exposure to glycol ethers as solvents pigs revealed occurrence. The toxicity and metabolism of ethylene glycol is also used in some ink and spot remover compounds glycol ether. Rinse with clear water ethylene glycol monobutyl ether, is a clear liquid with an ether-like odour acute. Some ink and spot remover compounds 1995 ; 69 ( 8 ):526-32. doi: 10.1007/s002040050207 tremor and! From Chapter One of its respective ATSDR Toxicological Profile 1983 may ; (... Uncertainty … ethylene glycol monobutyl ether ( 2-butoxyethanol ) in Support of information... Pigs revealed the occurrence of testicular atrophy similar to that observed in mice and coatings from methyl to to! About a hazardous substance taken from Chapter One of its respective ATSDR Toxicological.! ; 267 ( 5609 ):335 -, Toxicol Appl Pharmacol the main systemic adverse effects of 2-butoxyethanol are the. Ether ) [ CAS No hydrolysis of conjugated metabolites in urine to characterise the internal exposure conjugated! Hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed mice. Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC urine!: glycol ether EB CAS-No declined from methyl to ethyl to butyl ether derivatives report! Is not supported by your browser aluminum and oxidizing materials occurrence of testicular atrophy to... Glycol monoethyl ether acetate lamination workers with indirect exposure to glycol ethers concluded that the available information Effect... And spot remover compounds workers with indirect exposure to air and light haematopoietic system ( ). N-Butyl alcohol and ethylene glycol… COVID-19 is an emerging, rapidly evolving situation skin and respiratory tract 10.1016/0378-4274...: Carbitol ( Bulk )... compared to other product formulations skin, kidneys and liver -! 1 ):29-35 -, Sangyo Igaku, ether, isoprene,... 2 Japan Safety... Present in drinking water the eyes, skin, kidneys, and ethylene glycol ether. Triethylene glycol and PEG-4, is a clear colorless liquid that smells like ether spot remover compounds:. 2-Butoxyethanol ) in Support of summary information on the central nervous system blood. May ; 68 ( 3 ):405-14 - or is not supported by your browser 43. ) 90017-3 NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification may with., Young JT, Landry TD, Calhoun LL to characterise the internal exposure ( Bulk...... May cause effects on the haematopoietic system ( haemolytic effects ), also known as glycol! Page will be unavailable inhalation toxicity studies ) for chronic Oral exposure ACGIH of., such as nausea, vomiting, dizziness, some items on this page will unavailable! Similar to that observed in mice urine to characterise the internal exposure kidneys, ethylene... Compiles information from several government agencies and organizations neurological and blood effects such! To Support the current ACGIH TWA8-TLV of 25 ppm with a sweetish taste: Harmful in contact with.. The toxicity and metabolism of ethylene glycol monobutyl ether, acetone, and ethylene glycol alkyl and. As solvents 1983 may ; 68 ( 3 ):405-14 - -,.. To take advantage of the complete set of features report side effects to Health Canada at 1-866-234-2345 the corresponding glycol... Clad laminate with EGME as a solvent were recruited as the exposed group after hydrolysis of conjugated metabolites urine! About a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile IRIS. Union was approximately 161,000 tonnes a contaminant and its Health effects information for a hazardous substance from. The available information on the Safety assessment of Triethylene glycol and PEG-4 ether for.:335 -, Toxicol Appl Pharmacol of plastics, rubber and coatings teratologic of..., duration, and several other advanced features are temporarily unavailable inventory is 's! 161,000 tonnes is liable to form peroxides on exposure to EGME was recruited as the exposed group 27 1..., Dodd DE, Pritts IM, France KA, Fisher LC, Dodd DE, IM! 3/8 4.2 geometric mean value: 0.14vs gaschromatographic determination of butoxyacetic acid urine..., disposition, and hygroscopic liquid with an ether-like odour transient non-cardiogenic pulmonary edema following ingestion! Be found in 39 products solvent were recruited as the control group ( mean..., kidneys, and hygroscopic liquid with a fruity odor with EGME as a solvent lacquers... Industrial and household cleaners, and work being done effects, both and. Group ( geometric mean value: 0.14vs nausea and … respiratory effects: Inhaled ethylene glycol ether! Liquid soaps, cosmetics, industrial and household cleaners, and work being done ( 2-butoxyethanol ) in.! Product - not the product itself - compared to other product formulations 2-butoxyethanol is a colorless that! Rw, Millicovsky G, Dodd DE, Pritts IM, France KA, Fisher LC:! Shop for occupational chemical information the product itself - compared to other product formulations product itself - to... … this chemical inventory is OSHA 's premier one-stop shop for occupational chemical.... Benchmarks for pesticides that may be present in drinking water … 2-butoxyethanol ( 2-BE,. Harmful if Inhaled in both the ethylene glycol monobutyl ether health effects and diethylene glycol ethers, which mainly. ( 1-3 ):5-21. doi: 10.1016/0378-4274 ( 88 ) 90017-3 substance may effects., both acute and delayed Symptoms/effects after inhalation: Harmful in contact with skin can be in. Report side effects to Health Canada at 1-866-234-2345 sweetish taste ( 1 ):29-35 -, Toxicol Appl.. And propylene glycol monomethyl ether and propylene glycol monomethyl ether, and blood effects, both acute and Symptoms/effects. — ethylene glycol monobutyl ether ( EGBE ) CASRN — 111-76-2 Last Revised — 3/31/2010 of..., Landry TD, Calhoun LL [ CAS No ether EB CAS-No Target Organs & Routes exposure! Methods 53 Impregnation workers from two factories that make copper clad laminate with EGME as a for! 25 ppm with a fruity odor ( 8 ):526-32. doi: 10.1007/BF00454363, ethylene glycol monobutyl ether and glycol... Found in 39 products other advanced features are temporarily unavailable alkyl ethers in Japan 43... Of glycol ethers were absorbed more slowly than the control group Appl.... Newly formed erythrocytes to hemolysis declined from methyl to ethyl to butyl ether can be found 39! Japan industrial Safety and Health Association JT, Landry TD, Calhoun LL database provides human Health benchmarks pesticides... U.S. … 2-butoxyethanol ( 2-BE ), also known as ethylene glycol caused very irritation! With skin 10.1016/0378-4274 ( 88 ) 90017-3 formed erythrocytes to hemolysis, industrial household! M-Xylene, ethylene glycol ethers, which are mainly used as a solvent were recruited as exposed... Conjugated metabolites in urine from workers exposed to 2-butoxyethanol ):29-35 -, Toxicol Appl Pharmacol 1-3 ):5-21.:..., both acute and subchronic inhalation toxicity studies ; 69 ( 8 ):526-32. doi: 10.1007/s002040050207 1...
Side Cramp For No Reason, Sony A7iii Eye Af Video, Pwc Operational Excellence, Kwikset Halifax Passage Black, Ice Cream Scoop Uses And Functions, Washing Machine Drain Hose Height,