Polybutester is suitable in repair of tissues such as tendons where its elastic properties may be an advantage, particularly in the early phases of healing (Tan et al., 2003). Some of them have caused adverse reproductive and developmental effects in several animal species exposed by different routes of administration. Substance name : Glycol Ether DPM CAS-No. The glycol ethers are colorless liquids with a slight odor. Jane Lyttleton BSc (Hons) (NZ) MPhil (UK) Dip TCM (Aus) Cert Acup (China) Cert Herbal Med (China), in Treatment of Infertility with Chinese Medicine (Second Edition), 2013, Glycol ethers are a large group of organic solvents used in industry and the home as glass cleaners, carpet cleaners, floor cleaners and oven cleaners. The crystal structure of C18En for n ≥ 20 is a monoclinic system. Methoxyethanol is an E-series glycol ether derived from methanol and ethylene oxide. Use of methoxyethanol has declined in recent years due to risk management procedures and replacement by other substances. Dart, in Comprehensive Biomaterials II, 2017. formula C6H14O3 14 MW 134.18 14 Class glycol ether MP, ºC -76 14 BP, ºC 196 14 vapor pressure, torr @25ºC 0.126 14 evaporation rate (BuOAc=1) <0.01 34 specific gravity, 25ºC/25ºC 0.988 34 viscosity, cP @ 25ºC 3.85 38 flash point, ºC (closed cup) 93 2 The molar mass of diethylene glycol is 106.12 g/mol. How would we be able to predict that spermatocytes would be the responding cell based on these data from a Leydig cell line? On the other hand, for these to be changed in an unaffected cell type calls into question our ability to predict what the response would be in an animal (human or rodent) after such an exposure. Propylene glycol esters of fatty acids, where R1 and R2 represent a fatty acid and/or a hydrogen, and where at least one R represents a fatty acid. Mid-to slow evaporating solvent. Ethylene glycol and some of its derivatives are mildly toxic. Ether Bond: There is no ether bond in ethylene glycol. Vapor-phase triethylene glycol monomethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9.6 hours(SRC), calculated from its rate constant of 4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Figure 6. It is a viscous liquid. Other important glycols include 1,3-butanediol, used as a starting material for the manufacture of brake fluids and of plasticizers for resins; 1,4-butanediol, used in polyurethanes and in polyester resins for coatings and plasticizers, and for making butyrolactone, a valuable solvent and chemical intermediate; 2-ethyl-1,3-hexanediol, an effective insect repellent; and 2-methyl-2-propyl-1,3-propanediol, made into meprobamate, a widely used tranquilizer. EGME is metabolized to methoxyacetic acid, a metabolite that is just as toxic as the parent compound, and which is the active agent used in cell culture studies. CAS 111-76-2, EC Number 203-905-0, chemical formula C₄H₉OCH₂CH₂OH. Due to the formation of highly explosive peroxides in the air (not in the solution), they should be protected from heat and other ignition sources. Butoxytriglycol (Triethylene Glycol Monobutyl Ether) C 4 H 9 (OCH 2 CH 2 ) 3 OH The alkoxytriglycols are useful as low-volatility components in paint stripping formulations, as dye carriers for textile dye processes, as chemical process solvents and as intermediates for making esters for use as solvents, surfactants and plasticizers. The initial materials for the preparation of glycol ethers are ethane oxide (giving ethylene glycol ethers), propane oxide (giving propylene glycol ethers), and alcohols of the desired carbon chain length. Diethylene glycol monoethyl ether for synthesis. Offspring of women exposed occupationally during their first trimester had a high incidence of neural tube defects, multiple anomalies, and cleft lip. 112-07-2 - NQBXSWAWVZHKBZ-UHFFFAOYSA-N - Ethylene glycol monobutyl ether acetate - Similar structures search, synonyms, formulas, resource links, and other chemical information. May initiate the polymerization of isocyanates and epoxides. Supplier Structure 2006 Volume 14 Number 9, 1377-1388. The number of repeat units has significant effect on the melting, crystallizing temperature and enthalpy. Much of this has been further explored with the androgen receptor in the TM3 transformed mouse Leydig cell line. In a British study, glycol ether exposure was, however, related to low motile sperm count (Cherry et al., 2008). Glycol Ethers Glycol ethers are typically classified into two types; either E-series glycol ethers or P-series glycol ethers. It has embryotoxic and teratogenic effects in the offspring of exposed pregnant women. Often incorporated into latex emulsion coatings; can be used to prevent shocking (coagulation of emulsion) when hydrophobic solvents are used. Similar findings were reported in a rodent teratology study involving diethylene glycol and triethylene glycol but studies of propylene glycol have not observed any developmental effects at doses ranging from 1000 to 10 000 mg kg−1 day−1 (Driscoll et al., 1993; Enright et al., 2010). The molar mass of this compound is about 62.07 g/mol. This helped to identify early responses in Sertoli cells. Corrections? May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. Inhalation, dermal, and oral studies in pregnant rats, rabbits, and mice indicated fetotoxicity with resorption of fetuses and reduced fetal weight, as well as skeletal and cardiovascular abnormalities, increased incidences of major malformations, and minor anomalies. Alkoxyethanols can be metabolized to ethylene glycol by dealkylation through a secondary pathway that involves microsomal P450 mixed function oxidases. Omissions? The Leydig cells never appeared abnormal, although prostate weights were occasionally reduced in some studies. They verified much of the earlier work on the effects of MAA on nuclear receptors, but also reported MAA effects on lipid metabolism, cell death-related genes, cell differentiation, and cell adhesion, inter alia. It displays good handling characteristics and knot security while eliciting minimal tissue reaction (Huber et al., 1999). Of pregnancy acetic acid a monoclinic system LibreTexts - glycols and Glycerol cause birth defects in Biomedical Sciences,.. Content and ads data sheets and more information hemangiosarcoma [ 37,38 ], PEO, and waxes major... Development ( Multigner et al., 1997 ) cell function ) was evident following 4-day. 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