Rhabdomyosarcoma in children differs from the form of the disease typically seen in adults. 1 If tissue is limited, the pathologist can keep the frozen tissue aliquot used for frozen section (usually done to determine sample Journal of Surgical Research 2011;170 e243-251. Alveolar rhabdomyosarcoma should be considered in the differential diagnosis of tumors in juvenile dogs, especially when cytologic … Rhabdomyosarcoma (RMS) is an aggressive mesenchymal tumor most commonly diagnosed in the pediatric population, and when occurring in adults, tends to develop in the deep soft tissue of the limbs. The cells are arranged in variably sized nests separated by fibrous tissue septa. ARMS tumors resemble the alveoli tissue that can be found in the lungs. In places, the cells appear loosely dispersed, mimicking a pulmonary alveolar pattern. Parham DM, Ellison DA. Perez EA, Kassira N, Cheung MC, et al:. Alveolar rhabdomyosarcoma (ARMS) is a sub-type of the rhabdomyosarcoma soft tissue cancer family whose lineage is from mesenchymal cells and are related to skeletal muscle cells. Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) for pediatric oncology practice. Archives of Pathology and Laboratory Medicine 2006;130:1454-1465. • We report herein a series of 8 new cases of RMS of the uterus. It makes up a larger portion of RMS in older children, teens, and adults than in younger children (because ERMS is less common at older ages). • Awareness of this diagnosis is key as RMS can mimic other gynecologic malignancies. • Tumors consisted of 4 pleomorphic RMS, two alveolar RMS and 2 embryonal RMS. Rhabdomyosarcoma in Adults and Children: An Update. From a pediatric oncology point of view, RMS has traditionally been classified into alveolar (ARMS) and embryonal (ERMS) subtypes. Alveolar Rhabdomyosarcoma Alveolar rhabdomyosarcoma is evidenced by uniform cell population consisting of cells with a high nuclear-to-cytoplasmic ratio. Anaplastic cellular features may be seen in approximately 13% of all subtypes of rhabdomyosarcoma. Background Documentation Pediatric • Rhabdomyosarcoma 4.0.0.0 Resection 5 Explanatory Notes A. Submission of Tissue A minimum of 100 mg of viable tumor should be snap-frozen for potential molecular studies. Medscape.com Primary uterine rhabdomyosarcoma (RMS) is a rare soft tissue tumor in adults. A diagnosis of solid‐pattern alveolar rhabdomyosarcoma was made on the basis of morphologic and immunohistochemical results. Qualman S, Lynch J, Bridge J, et al:. Alveolar rhabdomyosarcoma (ARMS) ARMS typically affects all age groups equally. 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